Kathleen of Wisconsin USA has Adhesive Archnoiditis, a condition with constant inflammation and resulting pain. Her quality of life went from a 4 to an 8 out of 10 after taking LDN and does not experience any side effects. She started at 1.5 and increased to 6mg which she feels is her sweet spot. Other meds had little or no effects. She is so thankful to be living an almost normal life now.